Meaning:

Feel uncomfortable because you are in an unfamiliar situation.

If you feel like a fish out of water, you feel awkward or uncomfortable because you are in an unusual or unfamiliar situation.

Example:

I don't like going to the big parties they have. I always feel like a fish out of water there.

Todd is a country boy raised in a small town in Idaho and was like a fish out of water when he visited New York City.

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